Back to Search
Start Over
Fibronectin fibrillogenesis, a cell-mediated matrix assembly process
- Source :
-
Matrix Biology . Sep2005, Vol. 24 Issue 6, p389-399. 11p. - Publication Year :
- 2005
-
Abstract
- Abstract: The extracellular matrix provides a framework for cell adhesion, supports cell movement, and serves to compartmentalize tissues into functional units. Fibronectin is a core component of many extracellular matrices where it regulates a variety of cell activities through direct interactions with cell surface integrin receptors. Fibronectin is synthesized by many adherent cells which then assemble it into a fibrillar network. The assembly process is integrin-dependent and fibronectin–integrin interactions initiate a step-wise process involving conformational activation of fibronectin outside and organization of the actin cytoskeleton inside. During assembly, fibronectin undergoes conformational changes that expose fibronectin-binding sites and promote intermolecular interactions needed for fibril formation. In this review, the main steps of fibronectin assembly are described and recent studies on fibronectin conformational changes are discussed. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0945053X
- Volume :
- 24
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Matrix Biology
- Publication Type :
- Academic Journal
- Accession number :
- 18278542
- Full Text :
- https://doi.org/10.1016/j.matbio.2005.06.008