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On the study of BSA-loaded calcium-deficient hydroxyapatite nano-carriers for controlled drug delivery
- Source :
-
Journal of Controlled Release . Sep2005, Vol. 107 Issue 1, p112-121. 10p. - Publication Year :
- 2005
-
Abstract
- Abstract: Calcium-deficient hydroxyapatite (CDHA) nano-crystals incorporated with bovine serum albumin (BSA) to form BSA-loaded nano-carriers were synthesized via both in-situ and ex-situ processes. Amount of BSA uptake by the CDHA nano-crystals and subsequent release behaviors of the BSA-loaded nano-carriers were investigated. The amount of BSA uptake by CDHA decreases with increasing pH but a larger amount was observed in the ex-situ compared to in-situ process above pH=8.0. The release profile showed a bursting behavior for the nano-carrier prepared via the ex-situ process, which is probably due to the desorption of BSA molecules. In contrast, for the sample synthesized via the in-situ process at a higher pH level, a slower release profile without bursting behavior due to the dissolution of the BSA-incorporated CDHA crystal is seen from high solution TEM that indicates different extent of interaction between BSA and CDHA. On the other hand, for the nano-carriers prepared via the same process at lower pH level, a two-stage release profile was detected. An initial bursting release is due to the desorption of BSA from the CDHA surface, followed by a slow release as a result of the dissolution of the BSA-incorporated nano-crystals along its c-axis direction. [Copyright &y& Elsevier]
- Subjects :
- *HYDROXYAPATITE
*HYDROGEN-ion concentration
*SERUM albumin
*BLOOD plasma
Subjects
Details
- Language :
- English
- ISSN :
- 01683659
- Volume :
- 107
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Controlled Release
- Publication Type :
- Academic Journal
- Accession number :
- 18282666
- Full Text :
- https://doi.org/10.1016/j.jconrel.2005.05.025