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Design, syntheses, and biological evaluations of squamostolide and its related analogs
- Source :
-
Bioorganic & Medicinal Chemistry . Oct2005, Vol. 13 Issue 20, p5864-5872. 9p. - Publication Year :
- 2005
-
Abstract
- Abstract: Squamostolide and its related analogs were designed and synthesized for biological evaluation. All these compounds were tested for growth inhibition activities against human tumor cell lines, in which one of the compounds showed the most potent cytotoxicity among these derivatives against a full panel of 60 human cancer cell lines. The same compound also showed G2/M phase arrest and a weak apoptotic effect during flow cytometric analysis. [Copyright &y& Elsevier]
- Subjects :
- *CANCER cells
*CELL culture
*CELL lines
*TUMORS
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 13
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18283541
- Full Text :
- https://doi.org/10.1016/j.bmc.2005.05.050