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Front-line treatment of advanced non-small cell lung cancer with irinotecan and docetaxel: A multicentre phase II study

Authors :
Ziotopoulos, Panagiotis
Androulakis, Nikolaos
Mylonaki, Efthimia
Chandrinos, Vassilios
Zachariadis, Emmanouel
Boukovinas, Ioannis
Agelidou, Athina
Kentepozidis, Nikolaos
Ignatiadis, Michail
Vossos, Andreas
Georgoulias, Vassilis
Source :
Lung Cancer (01695002). Oct2005, Vol. 50 Issue 1, p115-122. 8p.
Publication Year :
2005

Abstract

Summary: Purpose: : To evaluate the efficacy and tolerance of the irinotecan plus docetaxel combination in patients with advanced non-small cell lung cancer (NSCLC). Patients and methods: : Thirty-nine chemotherapy-naïve patients with advanced NSCLC were treated with irinotecan 200mg/m2 followed by docetaxel 80mg/m2 intravenously on day 1 with granulocyte colony-stimulating factor (150μg/m2) support from day 2 to 9. Treatment was repeated every 3 weeks. Results: : A partial response was achieved in 9 (23%; 95% confidence interval 9.85–36.3%) patients; stable and progressive disease were observed in 10 (25.6%) and 20 (51.4%) patients, respectively. The median duration of response was 7.1 months and the median time to tumor progression 3 months. The median survival time was 10.8 months and the 1-year survival 42.2%. Four (10.3%) patients developed grade 4 neutropenia and all but one were complicated with fever; there was no treatment-related death. Nine (23.1%) patients developed grade 3 or 4 diarrhea while grade 2 or 3 fatigue occurred in nine (23.1%), and grade 3 mucositis in two (2.6%). Conclusion: : The combination of irinotecan/docetaxel is a relatively active non-platinum-based chemotherapy regimen with manageable toxicity, which could be given in an outpatient basis; this regimen merits to be further studied in order to improve its tolerance and evaluate its clinical relevance in patients who can not tolerate platinum-based doublets. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
01695002
Volume :
50
Issue :
1
Database :
Academic Search Index
Journal :
Lung Cancer (01695002)
Publication Type :
Academic Journal
Accession number :
18303520
Full Text :
https://doi.org/10.1016/j.lungcan.2005.05.004