Melanoma arising from pre-existing naevus in carriers of a germline CDKN2A pathogenic variant.

The article published in the British Journal of Dermatology explores the development of melanoma from pre-existing naevi in individuals with a germline CDKN2A pathogenic variant. The study found that 78% of melanomas in carriers of this variant originated from pre-existing naevi, with total-body photography being a useful tool for surveillance. The findings suggest the importance of routine monitoring and early detection in individuals with a CDKN2A pathogenic variant to prevent melanoma development. The study acknowledges limitations in sample size and patient demographics, emphasizing the need for further research in this area. [Extracted from the article]