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Modification of the content of plasma protein carbonyl groups in donors after granulocyte colony stimulating factor-induced stem cell mobilization
- Source :
-
Transfusion & Apheresis Science . Oct2005, Vol. 33 Issue 2, p141-146. 6p. - Publication Year :
- 2005
-
Abstract
- Abstract: Granulocyte-colony stimulating factor (G-CSF), the most established agent for the mobilization of stem cells in current clinical practice, could induce a condition of oxidative stress. Herein plasmatic levels of protein carbonyl groups (a biomarker of oxidative stress) were measured in a group of donors given recombinant human G-CSF (rHuG-CSF) at different times: (1) before starting rHuG-CSF administration, (2) on day 5 of rHuG-CSF administration, (3) on the same day immediately after the end of the first leukapheresis procedure and (4) one week after rHuG-CSF withdrawal. Plasma levels of protein carbonyl groups enhanced significantly in donors after 5 days of rHuG-CSF treatment and appeared further slightly increased following leukapheresis procedure; 7 days following rHuG-CSF withdrawal, they showed a tendency to normalization. These findings may contribute to better understand the oxidative reactions following rHuG-CSF treatment and leukapheresis. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 14730502
- Volume :
- 33
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Transfusion & Apheresis Science
- Publication Type :
- Academic Journal
- Accession number :
- 18322428
- Full Text :
- https://doi.org/10.1016/j.transci.2005.05.003