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Radical-mediated hydroxyalkylation of α,β-unsaturated esters

Authors :
Yajima, Tomoko
Saito, Chiaki
Nagano, Hajime
Source :
Tetrahedron. Oct2005, Vol. 61 Issue 43, p10203-10215. 13p.
Publication Year :
2005

Abstract

Abstract: The radical-mediated hydroxyalkylation of α,β-unsaturated esters with alkyl iodides, trialkylborane, water and KF in THF gave the corresponding α-hydroxy esters. The synthetic advantage of the method was demonstrated by a short-step total synthesis of (±)-tanikolide. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
00404020
Volume :
61
Issue :
43
Database :
Academic Search Index
Journal :
Tetrahedron
Publication Type :
Academic Journal
Accession number :
18342075
Full Text :
https://doi.org/10.1016/j.tet.2005.08.039