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Genetic deletion of CB1 receptors improves non-associative learning
- Source :
-
Behavioural Brain Research . Jul2005, Vol. 162 Issue 1, p161-164. 4p. - Publication Year :
- 2005
-
Abstract
- Abstract: Habituation (a form of non-associative learning) was measured by assessing locomotion in novel activity monitors in CB1 receptor knockout mice and juxtaposed to habituation measured in muscarinic M2, M4, and double M2/M4 receptor knockout mice. M2 and M2/M4, but not M4, receptor knockout mice appeared to have an impaired ability to habituate, whereas CB1 receptor knockout mice showed enhanced habituation compared to wild-type animals. We conclude that CB1 receptor gene invalidation improves habituation tentatively through an increase in cholinergic neurotransmission. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01664328
- Volume :
- 162
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Behavioural Brain Research
- Publication Type :
- Academic Journal
- Accession number :
- 18478789
- Full Text :
- https://doi.org/10.1016/j.bbr.2005.02.018