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Design, synthesis, and evaluation of proline based melanocortin receptor ligands
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jun2005, Vol. 15 Issue 11, p2819-2823. 5p. - Publication Year :
- 2005
-
Abstract
- Abstract: A series of proline based melanocortin ligands has been developed on the basis of initial piperazine leads by using a more conformationally rigid scaffold. A number of these novel ligands showed significant binding affinity for MC3 and MC4 receptors. [Copyright &y& Elsevier]
- Subjects :
- *LIGANDS (Biochemistry)
*BIOCHEMISTRY
*PROTEIN synthesis
*METAL scaffolding
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 18514087
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.03.120