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Gastrointestinal cytomegalovirus disease in patients with cancer: A two decade experience in a tertiary care cancer center
- Source :
-
European Journal of Cancer . Oct2005, Vol. 41 Issue 15, p2268-2279. 12p. - Publication Year :
- 2005
-
Abstract
- Abstract: Although gastrointestinal cytomegalovirus disease (GI-CMVd) is not common in cancer patients, it is associated with high morbidity and mortality. Herein, we review our 2-decade experience with GI-CMVd in such patient population at The University of Texas M.D. Anderson Cancer Center. Forty-seven patients were identified. Thirty-four patients (72%) had an underlying haematological malignancy, and 18 patients (38%) developed GI-CMVd following hematopoietic stem cell transplantation (HSCT). Nine (25%) of the 36 cancer patients with data available had AIDS. Upper-GI tract involvement was more common in patients with haematological malignancies than in those with solid tumours (P =0.02). Patients with AIDS were more likely to have colonic involvement than were those without AIDS (67% vs. 15%, P =0.006), and patients without AIDS were more likely to have gastric involvement (59% vs. 11%, P =0.01). The CMV-attributable mortality rate was 42%. Independent predictors of death by multivariate analysis included disseminated CMV and AIDS (P <0.01). The presentation of GI-CMVd varies according to the type of cancer, and AIDS. GI-CMVd is associated with a high mortality among cancer patients, particularly those with disseminated CMV disease or AIDS. [Copyright &y& Elsevier]
- Subjects :
- *CANCER patients
*AIDS
*CYTOMEGALOVIRUS diseases
*STEM cells
Subjects
Details
- Language :
- English
- ISSN :
- 09598049
- Volume :
- 41
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- European Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 18729898
- Full Text :
- https://doi.org/10.1016/j.ejca.2005.07.011