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Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Nov2005, Vol. 15 Issue 22, p4944-4948. 5p. - Publication Year :
- 2005
-
Abstract
- Abstract: The semi-synthesis, in vitro and in vivo biological evaluation of corosolic acid (1) and maslinic acid (2) are described. Compounds 1 and 2 represent a new class of inhibitors of glycogen phosphorylases. Both 1 and 2 inhibit the increase of fasted plasma glucose of diabetic mice induced by adrenaline. It is therefore proposed that naturally occurring pentacyclic triterpenes 1 and 2 might reduce blood glucose, at least in part, through inhibiting hepatic glycogen degradation. [Copyright &y& Elsevier]
- Subjects :
- *GLUCANS
*GLYCOGEN
*BLOOD plasma
*GLUCOSE
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 18729923
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.08.026