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Dynamics of tumour cords following changes in oxygen availability: A model including a delayed exit from quiescence
- Source :
-
Mathematical & Computer Modelling . May2005, Vol. 41 Issue 10, p1119-1135. 17p. - Publication Year :
- 2005
-
Abstract
- Abstract: In this paper, we investigate the formation of tumour cords (cylindrical arrangements of tumour cells around blood vessels) within a tumour tissue. The shrinkage and the expansion of the cord following a stepwise decrease or, respectively, increase of oxygen tension in the blood vessel are also described. The model represents the tumour cell population as a continuum and includes two novel aspects with respect to our previous works: cell death does not occur instantaneously, but is preceded by a reversible prenecrotic state; the recruitment of cells from quiescence into proliferation may require a recovery period. Model predictions are compared with experimental data reported by Hirst et al.. [Copyright &y& Elsevier]
- Subjects :
- *CANCER cells
*CELLS
*POPULATION
*SOCIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 08957177
- Volume :
- 41
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Mathematical & Computer Modelling
- Publication Type :
- Academic Journal
- Accession number :
- 18828239
- Full Text :
- https://doi.org/10.1016/j.mcm.2005.05.007