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Heterogeneity in α-thalassemia interactions in Malays, Chinese and Indians in Malaysia.
- Source :
-
Journal of Obstetrics & Gynaecology Research . Dec2005, Vol. 31 Issue 6, p540-546. 7p. - Publication Year :
- 2005
-
Abstract
- Aim: Interactions between different determinants of α-thalassemia raises considerable problems, particularly during pregnancies where antenatal diagnosis is necessary. This study aims to determine the different types of deletional α-thalassemia and Hemoglobin Constant Spring (HbCS), and their frequency in Malays, Chinese and Indians in Malaysia. Methods: DNA from 650 pregnant women from the Antenatal Clinic of the University of Malaya Medical Center in Kuala Lumpur, Malaysia who showed mean cell volume ≤89 fL and/or mean cell hemoglobin ≤28 pg were analyzed for the double α-globin gene South-East Asian deletion (--SEA), the -α3.7 and -α4.2 single α-globin gene deletions and HbCS. Results: One hundred and three (15.8%) of the pregnant women were confirmed as α-thalassemia carriers: 25 (3.8%) were α-thalassemia-1 carriers with the --SEA/αα genotype, 64 (9.8%) were heterozygous for the -α3.7 rightward deletion (-α3.7/αα), four (0.6%) were heterozygous for the -α4.2 leftward deletion (-α4.2/αα), nine (1.4%) were heterozygous for HbCS (αCSα/αα) and one (0.2%) was compound heterozygous with the -α3.7/αCSα genotype. The double α-globin gene --SEA deletion was significantly higher in the Chinese (15%) compared to the Malays (2.5%) and not detected in the Indians studied. The -α3.7 deletion was distributed equally in the three races. HbCS and -α4.2 was observed only in the Malays. Conclusion: The data obtained gives a better understanding of the interactions of the different α-thalassemia determinants in the different ethnic groups, thus enabling more rapid and specific confirmation of α-thalassemia in affected pregnancies where antenatal diagnosis is necessary. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THALASSEMIA
*FETAL diseases
*HEMOGLOBINS
*GLOBIN genes
*PRENATAL diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 13418076
- Volume :
- 31
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Obstetrics & Gynaecology Research
- Publication Type :
- Academic Journal
- Accession number :
- 18867010
- Full Text :
- https://doi.org/10.1111/j.1447-0756.2005.00333.x