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Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese.
- Source :
-
British Journal of Clinical Pharmacology . Dec2005, Vol. 60 Issue 6, p629-631. 3p. 1 Chart. - Publication Year :
- 2005
-
Abstract
- Aims To investigate the association of CYP2C9* 3 and * 6 with hyperlipidaemia in Chinese. Methods Four hundred and seventy-six Chinese participated in the study, including 211 uncomplicated hyperlipidaemic patients and 265 healthy controls. PCR-RFLP was used to identify CYP2C9* 3 and * 6. Results CYP2C9* 6 was not detected in this study. The allelic frequency of CYP2C9* 3 was 0.039 (95% CI 0.022, 0.056). A nonsignificant difference existed in CYP2C9* 3 frequencies between males and females ( P = 0.605, OR = 1.194, 95% CI 0.610, 2.336), patients and controls ( P = 0.063, OR = 0.506, 95% CI 0.244, 1.049) in the total population. However, in the female group, CYP2C9* 3 frequency in patients with hyperlipidaemia was significantly lower than that in controls ( P < 0.0001, OR = 0.062, 95% CI 0.008, 0.476). Conclusions The association of CYP2C9* 3 with hyperlipidaemia was specific for females in this Chinese population. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYPERLIPIDEMIA
*LIPID metabolism disorders
*DISEASES in women
*PATIENTS
Subjects
Details
- Language :
- English
- ISSN :
- 03065251
- Volume :
- 60
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- British Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 18904116
- Full Text :
- https://doi.org/10.1111/j.1365-2125.2005.02498.x