Nucleophilic difluoromethylation of carbonyl compounds using TMSCF2SO2Ph and Mg0-mediated desulfonylation

Authors :: Ni, Chuanfa
Hu, Jinbo
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Nov2005, Vol. 46 Issue 48, p8273-8277. 5p.
Publication Year :: 2005
Abstract: Abstract: A new nucleophilic difluoromethylation chemistry using fluoride-induced (phenylsulfonyl)difluoromethylation with TMSCF2SO2Ph followed by the magnesium-metal-mediated desulfonylation has been achieved. This methodology is compatible with both enolizable and non-enolizable aldehydes and ketones and has special advantage in the case of enolizable aldehydes. The new efficient desulfonylation method is considered to be environmentally benign due to the absence of mercury. [Copyright &y& Elsevier]

Language :: English
ISSN :: 00404039
Volume :: 46
Issue :: 48
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 18964312
Full Text :: https://doi.org/10.1016/j.tetlet.2005.09.162

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