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Defective Angiogenesis in Mice Lacking Endoglin.
- Source :
-
Science . 5/28/1999, Vol. 284 Issue 5419, p1534-1537. 4p. 38 Color Photographs, 2 Black and White Photographs, 1 Diagram. - Publication Year :
- 1999
-
Abstract
- Reports that loss-of-function mutations in the human endoglin gene ENG causes hereditary hemorrhagic telangiectasis (HHT1), a disease characterized by vascular malformations. Shows that by gestational day 11.5 mice lacking endoglin die from defective vascular development; Vasculogenesis unaffected in mice lacking transforming growth factor-beta (TGF-beta); Results of loss of endoglin; Need for endoglin for angiogenesis.
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 284
- Issue :
- 5419
- Database :
- Academic Search Index
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- 1903635