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RFX-1, a putative alpha Adducin interacting protein in a human kidney library
- Source :
-
FEBS Letters . Nov2005, Vol. 579 Issue 28, p6439-6443. 5p. - Publication Year :
- 2005
-
Abstract
- Abstract: Adducin regulates tubular absorption of sodium by modulating the expression levels of the sodium–potassium-ATPase in renal tubular cells. Adducin is a candidate gene in the pathogenesis of hypertension. Yeast two hybrid screen showed a specific interaction between human alpha Adducin and the regulatory factor for X box (RFX-1), a nuclear protein that down regulates the expression of several proteins in non neuronal cells. The interaction was confirmed in cells through coimmunoprecipitation and colocalization experiments. The binding of alpha Adducin to RFX-I and their nuclear co-localization suggests that Adducin can have a role in modulating the transcriptional regulating activity of RFX-I. [Copyright &y& Elsevier]
- Subjects :
- *YEAST
*HYPERTENSION
*ADENOSINE triphosphatase
*BLOOD circulation disorders
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 579
- Issue :
- 28
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 19114162
- Full Text :
- https://doi.org/10.1016/j.febslet.2005.10.040