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In Vivo Intravascular Ultrasound-Derived Thin-Cap Fibroatheroma Detection Using Ultrasound Radiofrequency Data Analysis
- Source :
-
Journal of the American College of Cardiology (JACC) . Dec2005, Vol. 46 Issue 11, p2038-2042. 5p. - Publication Year :
- 2005
-
Abstract
- Objectives: The purpose of this study was to assess the prevalence of intravascular ultrasound (IVUS)-derived thin-cap fibroatheroma (IDTCFA) and its relationship with the clinical presentation using spectral analysis of IVUS radiofrequency data (IVUS-Virtual Histology [IVUS-VH]). Background: Thin-cap fibroatheroma lesions are the most prevalent substrate of plaque rupture. Methods: In 55 patients, a non-culprit, non-obstructive (<50%) lesion was investigated with IVUS-VH. We classified IDTCFA lesions as focal, necrotic core-rich (≥10% of the cross-sectional area) plaques being in contact with the lumen; IDTCFA definition required a percent atheroma volume (PAV) ≥40%. Results: Acute coronary syndrome (ACS) (n = 23) patients presented a significantly higher prevalence of IDTCFA than stable (n = 32) patients (3.0 [interquartile range (IQR) 0.0 to 5.0] vs. 1.0 [IQR 0.0 to 2.8], p = 0.018). No relation was found between patient’s characteristics such as gender (p = 0.917), diabetes (p = 0.217), smoking (p = 0.904), hypercholesterolemia (p = 0.663), hypertension (p = 0.251), or family history of coronary heart disease (p = 0.136) and the presence of IDTCFA. A clear clustering pattern was seen along the coronaries, with 35 (35.4%), 31 (31.3%), 19 (19.2%), and 14 (14.1%) IDTCFAs in the first 10 mm, 11 to 20 mm, 21 to 30 mm, and ≥31 mm segments, respectively, p = 0.008. Finally, we compared the severity (mean PAV 56.9 ± 7.4 vs. 54.8 ± 6.0, p = 0.343) and the composition (mean percent necrotic core 19.7 ± 4.1 vs. 18.1 ± 3.0, p = 0.205) of IDTCFAs between stable and ACS patients, and no significant differences were found. Conclusions: In this in vivo study, IVUS-VH identified IDTCFA as a more prevalent finding in ACS than in stable angina patients. [Copyright &y& Elsevier]
- Subjects :
- *HEART blood-vessels
*ARTERIES
*ATHEROSCLEROTIC plaque
*HYPERCHOLESTEREMIA
Subjects
Details
- Language :
- English
- ISSN :
- 07351097
- Volume :
- 46
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of the American College of Cardiology (JACC)
- Publication Type :
- Academic Journal
- Accession number :
- 19127460
- Full Text :
- https://doi.org/10.1016/j.jacc.2005.07.064