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Autocrine role of vascular IL-15 in intimal thickening
- Source :
-
Biochemical & Biophysical Research Communications . Jan2006, Vol. 339 Issue 2, p618-623. 6p. - Publication Year :
- 2006
-
Abstract
- Abstract: Interleukin 15 (IL-15) is a pro-inflammatory cytokine that modulates T cell recruitment and activation, independent of antigen. It has been detected in human atherosclerotic plaques and atherosclerotic plaques of apoE−/− mice. IL-15 regulates fractalkine (FKN)–CX3CR1 chemokine signaling which is involved in atherogenesis and promotes SMC proliferation. We investigated the role of IL-15 in intimal thickening after arterial injury. Treatment of serum-stimulated SMC with IL-15 in vitro attenuated proliferation and suppressed CX3CR1 and FKN mRNA expression. The role of endogenous IL-15 in vivo was investigated in injured carotid arteries of mice. Periadventitial arterial injury resulted in increased IL-15 expression in the media and neointima, paralleled by increased IL-15 receptor α expression. Blockade of endogenous IL-15 increased intimal thickening. FKN and CX3CR1 expression increased after injury and were further augmented after IL-15 blockade. These data suggest that endogenous IL-15 attenuated intimal thickening after arterial injury. The potential mechanism of action is suppression of CX3CR1 signaling. [Copyright &y& Elsevier]
- Subjects :
- *ATHEROSCLEROTIC plaque
*ARTERIES
*CELLULAR immunity
*MESSENGER RNA
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 339
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 19167795
- Full Text :
- https://doi.org/10.1016/j.bbrc.2005.11.050