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Improved synthesis of 2′-amino-2′-deoxyguanosine and its phosphoramidite
- Source :
-
Bioorganic & Medicinal Chemistry . Feb2006, Vol. 14 Issue 3, p705-713. 9p. - Publication Year :
- 2006
-
Abstract
- Abstract: 2′-Amino-2′-deoxynucleosides and oligonucleotides containing them have proven highly effective for an array of biochemical applications. The guanosine analogue and its phosphoramidite derivatives have been accessed previously from 2′-amino-2′-deoxyuridine by transglycosylation, but with limited overall efficiency and convenience. Using simple modifications of known reaction types, we have developed useful protocols to obtain 2′-amino-2′-deoxyguanosine and two of its phosphoramidite derivatives with greater convenience, fewer steps, and higher yields than reported previously. These phosphoramidites provide effective synthons for the incorporation of 2′-amino-2′-deoxyguanosine into oligonucleotides. [Copyright &y& Elsevier]
- Subjects :
- *NUCLEOTIDES
*OLIGONUCLEOTIDES
*OLIGOADENYLATES
*NUCLEIC acids
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 14
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 19183782
- Full Text :
- https://doi.org/10.1016/j.bmc.2005.08.050