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Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors
- Source :
-
Brain Research . Dec2005, Vol. 1065 Issue 1/2, p147-151. 5p. - Publication Year :
- 2005
-
Abstract
- Abstract: The present study investigated a potential role for cannabinoid CB1 and CB2 receptors in capsaicin-evoked hypothermia. Capsaicin (1 mg/kg, s.c.) caused rapid and significant hypothermia in rats. Pretreatment with SR 141716A (1, 2.5 and 5 mg/kg, i.p.), a CB1 antagonist, or SR 144528 (1, 2.5 and 5 mg/kg, i.p.), a CB2 antagonist, did not affect capsaicin-induced hypothermia. In separate experiments, the hypothermia caused by WIN 55212-2 (5 mg/kg, i.m.), a cannabinoid agonist, was not significantly altered by capsazepine (10 and 30 mg/kg, i.p.) or SB 366791 (2 mg/kg, i.p.), a novel TRPV1 antagonist. These data suggest that capsaicin causes hypothermia by a CB1- and CB2-independent mechanism, and that WIN 55212-2 causes hypothermia by a TRPV1-independent mechanism. [Copyright &y& Elsevier]
- Subjects :
- *CAPSAICIN
*HYPOTHERMIA
*BODY temperature
*CANNABINOIDS
Subjects
Details
- Language :
- English
- ISSN :
- 00068993
- Volume :
- 1065
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Brain Research
- Publication Type :
- Academic Journal
- Accession number :
- 19201112
- Full Text :
- https://doi.org/10.1016/j.brainres.2005.10.026