Back to Search
Start Over
Tp53-gene transfer induces hypersensitivity to low doses of X-rays in glioblastoma cells: a strategy to convert a radio-resistant phenotype into a radiosensitive one
- Source :
-
Cancer Letters . Jan2006, Vol. 231 Issue 1, p102-112. 11p. - Publication Year :
- 2006
-
Abstract
- Abstract: Tp53 is frequently mutated or inactivated in glioblastomas. Due to the impairment of p53 activity, glioblastomas show a high degree of radioresistance. In an attempt to convert the radioresistant phenotype to a more radiosensitive one, we evaluated the efficacy of the combination of Adp53 gene transfer and X-ray irradiation. The combination of Adp53, at low multiplicity in order to mimic the low in vivo efficiency of virus-mediated gene delivery, with X-ray irradiation resulted in a marked decrease of glioblastoms cell survival. Interestingly, Adp53 was able to induce low dose (<2Gy) hypersensitivity. The data suggest the possibility for the development of new therapeutic strategies. [Copyright &y& Elsevier]
- Subjects :
- *IRRADIATION
*GENETIC transformation
*PHOTOTHERAPY
*MEDICAL electronics
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 231
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 19201761
- Full Text :
- https://doi.org/10.1016/j.canlet.2005.01.033