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COMT Val158Met and BDNF C270T polymorphisms in schizophrenia: a case-control study
- Source :
-
Schizophrenia Research . Feb2005, Vol. 73 Issue 1, p27-30. 4p. - Publication Year :
- 2005
-
Abstract
- Abstract: In a multicenter study involving 217 subjects of European ancestry [106 patients with schizophrenia and 111 healthy subjects], we tested the hypothesis that the catechol-O-methyl transferase (COMT) Val158Met and/or the brain-derived neurotrophic factor (BDNF) C270T gene polymorphisms are associated with schizophrenia. The COMT and BDNF genotype and their allele distribution did not differ between patients with schizophrenia and healthy comparison subjects. These results do not support the hypothesis that the COMT Val158Met or BDNF C270T gene polymorphisms are associated with liability to schizophrenia. [Copyright &y& Elsevier]
- Subjects :
- *SCHIZOPHRENIA
*GENETIC polymorphisms
*GENETIC research
*PSYCHOSES
Subjects
Details
- Language :
- English
- ISSN :
- 09209964
- Volume :
- 73
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Schizophrenia Research
- Publication Type :
- Academic Journal
- Accession number :
- 19266333
- Full Text :
- https://doi.org/10.1016/j.schres.2004.06.017