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O-GlcNAcase Catalyzes Cleavage of Thioglycosides without General Acid Catalysis.
- Source :
-
Journal of the American Chemical Society . 12/14/2005, Vol. 127 Issue 49, p17202-17203. 2p. - Publication Year :
- 2005
-
Abstract
- This article focuses on the O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis. In Nature, thioglycosidase activity has been identified in extracts from several organisms. Nevertheless, the only glycosidases with well-defined thioglycosidase activity having been identified are the plant myrosinases. Elegant studies have shown that, unlike all other glycosidases which have a highly conserved general acid catalytic residue to facilitate departure of an alkoxide leaving group, the family myrosinases lack such a group.
- Subjects :
- *CATALYSTS
*SURFACE chemistry
*CATALYSIS
*ENZYMES
*GLYCOSIDASES
*ALKOXIDES
Subjects
Details
- Language :
- Slovak
- ISSN :
- 00027863
- Volume :
- 127
- Issue :
- 49
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 19332498
- Full Text :
- https://doi.org/10.1021/ja0567687