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Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides
- Source :
-
Bioorganic & Medicinal Chemistry . Feb2006, Vol. 14 Issue 4, p997-1006. 10p. - Publication Year :
- 2006
-
Abstract
- Abstract: Structure–activity relationship studies were employed to synthesize a series of 3- and 3,4-substituted benzamides from 3-amino-2-cyclohexenones. An improved method for the synthesis of benzamides from 3-amino-2-cyclohexenones is presented which provided significantly higher yields (71–79%) for the reported compounds. NMR and X-ray structural analyses were undertaken to note the possible intra- and intermolecular interactions of the synthesized analogs. Molecular modeling studies were used to determine the minimized configuration and were compared to their X-ray structures for correlation. These new entities were evaluated as potential anticonvulsants and type IV phosphodiesterase inhibitors (PDE4). [Copyright &y& Elsevier]
- Subjects :
- *ANTICONVULSANTS
*PHOSPHODIESTERASES
*BENZAMIDE
*PHOSPHATASES
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 14
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 19355994
- Full Text :
- https://doi.org/10.1016/j.bmc.2005.09.023