Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila.

The article discusses the study "Misspecified Cells Die by an Active Gene-Directed Process, and Inhibition of This Death Results in Cell Fate Transformation in Drosophila," by Christian Werz, Tom V. Lee et al. Incorrectly specified cells often result to cell death or are transformed to adopt a different cell fate during development. Large numbers of mis-specified cells die synchronously in many developmental mutants in Drosophila. Upregulation of hid occurs in oskar mutants and other segmentation mutants.