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Catalytic Allylic Alkylation via the Cross-Dehydrogenative-Coupling Reaction between Allylic sp3 C--H and Methylenic sp3 C--H Bonds.
- Source :
-
Journal of the American Chemical Society . 1/11/2006, Vol. 128 Issue 1, p56-57. 2p. - Publication Year :
- 2006
-
Abstract
- This article focuses on the catalytic allylic alkylation via the cross-dehydrogenative-coupling (CDC) reaction between allylic sp3 C-H and methylenic sp3 C-H bonds. The palladium catalyzed allylic alkylation is one of the most important reactions for constructing C-C bonds in modern organic synthesis. The direct utilization of an allylic C-H bond rather than an allylic functional group would avoid the need to synthesize the allylic functional group, thus leading to increased synthetic efficiency. The development of a catalytic allylic alkylation via a CDC reaction would be quite desirable. With the optimized reaction conditions established, various substrates were subjected to the allylic alkylation reactions.
- Subjects :
- *CHEMICAL reactions
*HYDROCARBONS
*PALLADIUM
*CHEMICAL bonds
*ALKYLATION
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 128
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 19519327
- Full Text :
- https://doi.org/10.1021/ja056541b