Catalytic Allylic Alkylation via the Cross-Dehydrogenative-Coupling Reaction between Allylic sp3 C--H and Methylenic sp3 C--H Bonds.

This article focuses on the catalytic allylic alkylation via the cross-dehydrogenative-coupling (CDC) reaction between allylic sp3 C-H and methylenic sp3 C-H bonds. The palladium catalyzed allylic alkylation is one of the most important reactions for constructing C-C bonds in modern organic synthesis. The direct utilization of an allylic C-H bond rather than an allylic functional group would avoid the need to synthesize the allylic functional group, thus leading to increased synthetic efficiency. The development of a catalytic allylic alkylation via a CDC reaction would be quite desirable. With the optimized reaction conditions established, various substrates were subjected to the allylic alkylation reactions.