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Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers.
- Source :
-
PLoS Pathogens . Jan2006, Vol. 2 Issue 1, pe1-0013. 9p. 6 Graphs. - Publication Year :
- 2006
-
Abstract
- The filoviruses Marburg virus and Ebola virus (EBOV) quickly outpace host immune responses and cause hemorrhagic fever, resulting in case fatality rates as high as 90% in humans and nearly 100% in nonhuman primates. The development of an effective therapeutic for EBOV is a daunting public health challenge and is hampered by a paucity of knowledge regarding filovirus pathogenesis. This report describes a successful strategy for interfering with EBOV infection using antisense phosphorodiamidate morpholino oligomers (PMOs). A combination of EBOV-specific PMOs targeting sequences of viral mRNAs for the viral proteins (VPs) VP24, VP35, and RNA polymerase L protected rodents in both pre- and post-exposure therapeutic regimens. In a prophylactic proof-of-principal trial, the PMOs also protected 75% of rhesus macaques from lethal EBOV infection. The work described here may contribute to development of designer, "druggable" countermeasures for filoviruses and other microbial pathogens. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MARBURG virus
*EBOLA virus disease
*IMMUNE response
*HEMORRHAGIC fever
*OLIGOMERS
Subjects
Details
- Language :
- English
- ISSN :
- 15537366
- Volume :
- 2
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- PLoS Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 19529895
- Full Text :
- https://doi.org/10.1371/journal.ppat.0020001