Back to Search
Start Over
Contractile reactivity of human myometrium in isolated non-pregnant uteri.
- Source :
-
Human Reproduction . Jan2006, Vol. 21 Issue 1, p36-45. 10p. - Publication Year :
- 2006
-
Abstract
- BACKGROUND: Perfusion of the isolated uterus has been shown to be a feasible experimental system for studies of the human endometrium and myometrium. Utilizing our established experimental perfusion model we perfused 20 uteri for 27 h and investigated the contractile reactivity of the myometrium in response to 17β-estradiol (E2) and oxytocin (OT). METHODS: Uteri of group A (n = 4) were stimulated with OT; group B (n = 4) was treated continuously with E2; group C (n = 4) received both E2 and OT for 27 h; group D (n = 4) was perfused for 27 h with E2 with the addition of OT for the last 3 h of the experiment; group E (n = 4) as control group remained without any treatment. The pressure and duration of uterine contractions were recorded during the entire perfusion period using intramural and endoluminal pressure catheters. RESULTS: Compared to the other treatment groups and controls, the most effective myometrial activity was achieved in group D during the OT stimulation period. No relevant myometrial activity was detected in the control group. CONCLUSIONS: Continuous E2 treatment, with the addition of OT for the last 3 h of the 27 h perfusion period, led to the most pronounced uterotonic effects in the presented experimental condition. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MYOMETRIUM
*ENDOMETRIUM
*OXYTOCIN
*UTERUS
Subjects
Details
- Language :
- English
- ISSN :
- 02681161
- Volume :
- 21
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Human Reproduction
- Publication Type :
- Academic Journal
- Accession number :
- 19619797
- Full Text :
- https://doi.org/10.1093/humrep/dei295