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Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome.

Authors :
Oka, Shin-ichi
Liu, Wenrui
Masutani, Hiroshi
Hirata, Hiromi
Shinkai, Yoichi
Yamada, Shu-ichi
Yoshida, Toru
Nakamura, Hajime
Yodoi, Junji
Source :
FASEB Journal. Jan2006, Vol. 20 Issue 1, p121-123. 3p. 1 Color Photograph, 1 Diagram, 1 Chart, 2 Graphs.
Publication Year :
2006

Abstract

The article discusses impaired fatty acid utilization in thiredoxin binding protein-2 (TBP-2)-deficient mice. TBP-2-/- mice are predisposed to death with severe bleeding during fasting. Glucose supplementation corrected the fatal anomaly in TBP-2-/- mice, while fatty acids were unable to do so.

Details

Language :
English
ISSN :
08926638
Volume :
20
Issue :
1
Database :
Academic Search Index
Journal :
FASEB Journal
Publication Type :
Academic Journal
Accession number :
19657443
Full Text :
https://doi.org/10.1096/fj.05-4439fje