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Caveolin-1 as a potential new therapeutic target in multiple myeloma
- Source :
-
Cancer Letters . Feb2006, Vol. 233 Issue 1, p10-15. 6p. - Publication Year :
- 2006
-
Abstract
- Abstract: Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22–24kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma. [Copyright &y& Elsevier]
- Subjects :
- *MULTIPLE myeloma
*ISOPENTENOIDS
*CHOLESTEROL
*B cell lymphoma
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 233
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 19696456
- Full Text :
- https://doi.org/10.1016/j.canlet.2005.02.035