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The Calcineurin Phosphatase Complex Modulates Immunogenic B Cell Responses
- Source :
-
Immunity (10747613) . Feb2006, Vol. 24 Issue 2, p141-152. 12p. - Publication Year :
- 2006
-
Abstract
- Summary: A series of signal-directed transitions regulates the development of distinct populations of self-tolerant B cells and ultimately the production of antibody-producing plasma cells. We studied the role of calcineurin/NFAT signaling in B cells by deleting the regulatory b1 subunit of calcineurin specifically in B cells. Follicular (FO) and marginal zone (MZ) B cells develop normally in these mice, but B1 cell numbers are reduced. In vitro, calcineurin b1-deficient B cells have a cell-intrinsic proliferation defect downstream of the B cell receptor. These mice have higher total serum IgM despite the absence of B1 cells and have enhanced T cell-independent-1 responses. Conversely, mice with calcineurin b1-deficient B cells develop larger germinal centers and have reduced plasma cell development and antigen-specific antibody production during T cell-dependent immune responses. By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo. [Copyright &y& Elsevier]
- Subjects :
- *B cells
*PLASMA cells
*IMMUNOGLOBULINS
*CYTOLOGICAL research
*MICE genetics
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Volume :
- 24
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Immunity (10747613)
- Publication Type :
- Academic Journal
- Accession number :
- 19696831
- Full Text :
- https://doi.org/10.1016/j.immuni.2005.12.013