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Synaptic Vesicles: Turning Reluctance Into Action.
- Source :
-
Neuroscientist . Feb2006, Vol. 12 Issue 1, p11-15. 5p. 1 Color Photograph, 2 Diagrams, 1 Graph. - Publication Year :
- 2006
-
Abstract
- Vesicle availability partly determines the efficacy of synaptic communication in the CNS. The authors recently found that some hippocampal glutamate vesicles exhibit reluctance to exocytose during short, high-frequency action potential trains. These same vesicles can be "coaxed" into exocytosis by increased Ca2+ entry, by direct depolarization of synaptic terminals, or by challenge with hypertonic sucrose, a tool used to cause fusion of the population of release-ready synaptic vesicles. Interestingly, the authors did not find evidence of reluctance at hippocampal GABA synapses, suggesting that vesicle reluctance might be a negative feedback mechanism to prevent runaway excitation. It is also possible that synapses exhibit reluctance to retain a dormant population of readily accessible vesicles, ready to respond to triggers such as enhanced Ca2+ influx or neuromodulators. Recent work from the calyx of Held synapse suggests that reluctance might arise from inactivation of Ca2+ channels. The authors review this work, along with several other potential mechanisms of reluctance. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ORGANELLES
*SYNAPSES
*CENTRAL nervous system
*EXOCYTOSIS
*NEUROSCIENCES
Subjects
Details
- Language :
- English
- ISSN :
- 10738584
- Volume :
- 12
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Neuroscientist
- Publication Type :
- Academic Journal
- Accession number :
- 19728497
- Full Text :
- https://doi.org/10.1177/1073858405282431