Solid phase synthesis of 3-(5-arylpyridin-2-yl)-4-hydroxycoumarins

Authors :: Liu, Yannan
Mills, Aaron D.
Kurth, Mark J.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Mar2006, Vol. 47 Issue 12, p1985-1988. 4p.
Publication Year :: 2006
Abstract: Abstract: A solid phase strategy has been developed for the synthesis of 3-(5-arylpyridin-2-yl)-4-hydroxycoumarins. The key transformation is an intramolecular ipso substitution reaction which forms the coumarin heterocycle and culminates with cleavage of product from the polymer support. The pyridine moiety at C3 can be further modified with Suzuki coupling. A sample library with two diversity elements has been synthesized to demonstrate this ipso substation-based cyclo-elimination strategy. [Copyright &y& Elsevier]

Subjects :: *CHEMICAL reactions
*ANTICOAGULANTS
*ORGANIC compounds
*PYRIDINE

Language :: English
ISSN :: 00404039
Volume :: 47
Issue :: 12
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 19768936
Full Text :: https://doi.org/10.1016/j.tetlet.2006.01.069