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Biological monitoring of welders exposed to aluminium
- Source :
-
Toxicology Letters . Apr2006, Vol. 162 Issue 2/3, p239-245. 7p. - Publication Year :
- 2006
-
Abstract
- Abstract: To evaluate an adequate strategy for biological monitoring of aluminium (Al), a group of 62 Al welders (age in 1999: 23–51 years, median 35 years) was surveyed annually from 1999 to 2003 by determination of pre- and post-shift Al in urine and plasma. Biomonitoring was supplemented by personal air measurements of the total dust concentration. The welders’ internal exposure was compared to the exposure of 60 non-exposed assembly workers (age in 1999: 21–51 years, median: 36 years) who were surveyed in 1999, 2001 and 2003. Having a nearly constant dust exposure, median concentrations of Al in urine (Al in plasma) of the welders decreased from 40.1μg/g to 19.8μg/g creatinine (8.7 to 4.6μg/l). For the control group the median levels of Al in urine (plasma) ranged from 4.8μg/g to 5.2μg/g creatinine (2.4–4.3μg/l) indicating a higher sensitivity for the marker Al in urine. No systematic differences have been found between pre- and post-shift internal exposure. This might be caused by the slow elimination kinetics and low systemic bioavailability of Al. A correlation analysis did not yield close relationships between dust exposure, Al in plasma and Al in urine underlining the importance of biomonitoring for assessment of Al exposure. [Copyright &y& Elsevier]
- Subjects :
- *BIOINDICATORS
*BIOLOGICAL monitoring
*BIOMARKERS
*TOXICOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 03784274
- Volume :
- 162
- Issue :
- 2/3
- Database :
- Academic Search Index
- Journal :
- Toxicology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 19770041
- Full Text :
- https://doi.org/10.1016/j.toxlet.2005.09.018