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Differential Astrocyte Response to Theiler’s Murine Encephalomyelitis Virus Infection.
- Source :
-
Intervirology . Sep/Oct2005, Vol. 48 Issue 5, p279-284. 6p. 1 Diagram, 2 Graphs. - Publication Year :
- 2005
-
Abstract
- Objectives: We aimed to address if selective astrocyte apoptosis is involved in the lack of murine demyelinating disease following infection by the L*-1 variant of Theiler’s virus. In addition, we investigated whether L*-1-infected astrocytes were able to selectively express molecules whose effects would play a role as pathogenic factors. Methods: Murine cultured astrocytes were infected with two Theiler viruses, the DA strain and the mutated DA variant L*-1, which does not synthesize the out of frame L* protein. Results: Neither DA nor L*-1 provoked apoptosis, although they replicated in astrocytes inducing GFAP and iNOS expression, as well as subsequent nitric oxide production. In addition, both viruses caused an enhanced expression of ICAM-1, VCAM-1 and decay accelerating factor (DAF). In this connection, values of VCAM-1 and DAF induced by L*-1 were higher and lower, respectively, than those induced by DA. Conclusions: Since no apoptosis was found, such mechanism would not be involved in the lack of TMEV-induced demyelinating disease by L*-1. In contrast, selective expression of VCAM-1 and DAF molecules induced by L*-1 could have a role in virus clearance from the central nervous system. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *ASTROCYTES
*APOPTOSIS
*CELL death
*INFECTION
*GENE expression
Subjects
Details
- Language :
- English
- ISSN :
- 03005526
- Volume :
- 48
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Intervirology
- Publication Type :
- Academic Journal
- Accession number :
- 19918593
- Full Text :
- https://doi.org/10.1159/000085095