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Structures of the core oligosaccharide and O-units in the R- and SR-type lipopolysaccharides of reference strains of Pseudomonas aeruginosa O-serogroups.
- Source :
-
FEMS Immunology & Medical Microbiology . Feb2006, Vol. 46 Issue 1, p85-99. 15p. 4 Charts, 3 Graphs. - Publication Year :
- 2006
-
Abstract
- Highly phosphorylated core oligosaccharides and those substituted with one O-antigen repeating unit were obtained by mild acid degradation or strong alkaline hydrolysis of lipopolysaccharide samples from 23 reference strains representing all Pseudomonas aeruginosa O-serogroups. Studies by high-resolution electrospray ionization mass spectrometry and two-dimensional NMR spectroscopy revealed both conserved and variable structural features of the lipopolysaccharides of various O-serogroups. The upstream terminal saccharide of the O-antigen, which contributes most to the immunospecificity of the bacteria, was defined in 11 from a total of 13 O-serogroups. The data obtained link together the known biosynthesis pathways, genetics and serology of the P. aeruginosa lipopolysaccharide. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09288244
- Volume :
- 46
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- FEMS Immunology & Medical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 20005123
- Full Text :
- https://doi.org/10.1111/j.1574-695X.2005.00004.x