Back to Search
Start Over
Ex vivo biochemical analysis of CFTR in human rectal biopsies
- Source :
-
BBA: Molecular Basis of Disease . Apr2006, Vol. 1762 Issue 4, p393-397. 5p. - Publication Year :
- 2006
-
Abstract
- Abstract: This report describes the first biosynthetic analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) in freshly excised human rectal biopsies. Expression of functional CFTR was assessed by intestinal current measurement (ICM) prior to biosynthetic studies. Several structural features of CFTR are found to be comparable to those established in CFTR-expressing cell lines. Interestingly, maturation of CFTR increases substantially in tissue incubated at 26 °C. Our data provide a solid basis for future studies on the characterisation of CFTR in pathological cases. [Copyright &y& Elsevier]
- Subjects :
- *CYSTIC fibrosis
*CELL lines
*BIOPSY
*GENETIC disorders
Subjects
Details
- Language :
- English
- ISSN :
- 09254439
- Volume :
- 1762
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- BBA: Molecular Basis of Disease
- Publication Type :
- Academic Journal
- Accession number :
- 20011362
- Full Text :
- https://doi.org/10.1016/j.bbadis.2006.01.007