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Detection of Dysplastic Intestinal Adenomas Using a Fluorescent Folate Imaging Probe.
- Source :
-
Molecular Imaging . Jan2005, Vol. 4 Issue 1, p67-74. 8p. - Publication Year :
- 2005
-
Abstract
- Macrophages have long been recognized as a prominent component of tumors. Activated macrophages overexpress folate receptors and we used this phenomenon to image inflammatory reactions in colon dysplasia using a fluorescent folate probe (FFP). APCδ468 mice injected with FFP showed fluorescent adenomas (target-to-background ratio, adenoma vs. adjacent normal mucosa, of 2.46 ± 0.41), significantly higher (p < .001) than adenomas in animals injected with a non-folate-containing control probe. Fluorescence-activated cell-sorting analysis revealed a 3-fold higher content of Mac1-positive cells in colonic adenomas compared with normal adjacent mucosa (6.8% vs. 2.2%), and confirmed the source of FFP-positive cells to be primarily an F4/80-positive macrophage subpopulation. Taken together, these results indicate that FFP potentially can be used to image dysplastic intestinal adenomas in vivo. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ADENOMA
*DYSPLASIA
*MACROPHAGES
*COLON cancer
*TUMORS
Subjects
Details
- Language :
- English
- ISSN :
- 15353508
- Volume :
- 4
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 20056554
- Full Text :
- https://doi.org/10.1162/15353500200504199