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Structure–activity relationship of thiopyrimidines as mGluR5 antagonists
- Source :
-
Bioorganic & Medicinal Chemistry Letters . May2006, Vol. 16 Issue 9, p2467-2469. 3p. - Publication Year :
- 2006
-
Abstract
- Abstract: Structure–activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 20184152
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.01.100