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Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jun2006, Vol. 16 Issue 11, p2877-2881. 5p. - Publication Year :
- 2006
-
Abstract
- Abstract: An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases α and β and human terminal deoxynucleotidyl transferase (TdT). [Copyright &y& Elsevier]
- Subjects :
- *LIPIDS
*GENETICS
*DNA polymerases
*TRANSFERASES
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 20573975
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.03.005