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Decreased morphine analgesia in rat overexpressing β-arrestin 2 at periaqueductal gray
- Source :
-
Neuroscience Letters . May2006, Vol. 400 Issue 1/2, p150-153. 4p. - Publication Year :
- 2006
-
Abstract
- Abstract: β-arrestin 2 plays important physiological roles in regulating the function of the μ opioid receptor (μOR) in vivo. Periaqueductal gray (PAG) is a potential structure where morphine produces its antinociception, but it is unclear whether β-arrestin 2 plays its regulatory effect on morphine at PAG. In the present study β-arrestin 2 overexpression was induced by adenovirus at PAG of rats. Morphine was administrated in these rats through PAG microinjection and systemic administration. The antinociceptive effects of morphine were abolished in rats received microinjection of morphine at PAG and partially attenuated in rats received systemic administration of morphine. These findings support the notion that PAG is an important site where β-arrestin 2 plays its regulatory effects on morphine analgesia. [Copyright &y& Elsevier]
- Subjects :
- *MORPHINE
*PERIAQUEDUCTAL gray matter
*OPIOID receptors
*ADENOVIRUS diseases
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 400
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 20733639
- Full Text :
- https://doi.org/10.1016/j.neulet.2006.02.071