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Interaction between c-Abl and Arg Tyrosine Kinases and Proteasome Subunit PSMA7 Regulates Proteasome Degradation
- Source :
-
Molecular Cell . May2006, Vol. 22 Issue 3, p317-327. 11p. - Publication Year :
- 2006
-
Abstract
- Summary: Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (α4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is compromised. Notably, cells expressing a phosphorylation mutant of PSMA7(Y153F) display impaired G1/S transition and S/G2 progression, highlighting the biological significance of tyrosine phosphorylation of a proteasome subunit as an important cellular regulatory control. [Copyright &y& Elsevier]
- Subjects :
- *PROTEIN-tyrosine kinases
*PROTEOLYSIS
*PHOSPHORYLATION
*CHEMICAL reactions
Subjects
Details
- Language :
- English
- ISSN :
- 10972765
- Volume :
- 22
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Molecular Cell
- Publication Type :
- Academic Journal
- Accession number :
- 20733795
- Full Text :
- https://doi.org/10.1016/j.molcel.2006.04.007