Square-wave adsorptive stripping voltammetric determination of danazol in capsules

Abstract: Based on the interfacial adsorptive character of danazol onto the hanging mercury drop electrode (HMDE), a simple and sensitive square-wave adsorptive stripping voltammetric (SW-AdSV) procedure for the electrochemical analysis of this drug in pharmaceutical formulations has been developed and validated. Cyclic and SW-AdSV voltammograms showed a single well-defined irreversible cathodic peak. Various chemical and instrumental parameters affecting the monitored electroanalytical response were investigated and optimized for the danazol determination. Under these optimized conditions the SW-AdSV peak current showed a linear dependence on drug concentration over the range 7.5×10−8–3.75×10−7 moll−1 (r =0.999) with estimated detection limit (at a S/N ratio of 3) of 5.7×10−9 moll−1 (1.78ngml−1). A mean recovery of 100.9±1.2% and relative standard deviation of 1.07% were achieved. Possible interferences by substances usually present in the pharmaceutical tablets and formulations were also evaluated. The proposed electrochemical procedure was successfully applied for the determination of danazol in pharmaceutical capsules (Danol™ 100mg) with mean recoveries of 100.48±0.87%. Results of the developed SW-AdSV method were comparable with those obtained by reported analytical procedures. [Copyright &y& Elsevier]