Back to Search
Start Over
Is elevated level of soluble endothelial protein C receptor a new risk factor for retinal vein occlusion?
- Source :
-
Clinical & Experimental Ophthalmology . May/Jun2006, Vol. 34 Issue 4, p305-311. 7p. 3 Charts, 1 Graph. - Publication Year :
- 2006
-
Abstract
- Background: To evaluate the systemic and thrombophilic risk factors for retinal vein occlusion (RVO) and to determine whether the elevated level of soluble endothelial protein C receptor (sEPCR) is a risk factor for thrombosis. Methods: In this case–control study, 56 patients with central RVO (CRVO), 26 patients with branch RVO (BRVO) and 78 healthy sex- and age-matched subjects were enrolled. Following ophthalmological examination, venous blood was analysed for glucose, lipid profile, lipoprotein (a), homocysteine, activated partial thromboplastin time, fibrinogen, factor VIII, protein C activity, protein S activity, activated protein C resistance, antithrombin III activity, lupus anticoagulant, anti-cardiolipin antibody, anti-phospholipid antibody, sEPCR, factor V Leiden mutation and prothrombin G20210A mutation. Results: Apart from hypertension, glaucoma, lipoprotein (a), homocysteine and factor VIII, elevated levels of sEPCR were found to be a risk factor for CRVO (odds ratio, 1.02; 95% confidence interval, 1.007–1.028; P = 0.001). Patients with CRVO had significantly higher levels of sEPCR than those with BRVO and controls (respectively, 160.1 ± 83.8, 116.8 ± 65.2 and 111.3 ± 60.5; P = 0.005). Moreover, 39% of patients with CRVO had levels of sEPCR more than 200 ng/mL, and only 5% of controls and 11% of patients with BRVO had similar high levels. Conclusions: Besides known classical risk factors, elevated levels of sEPCR seem to be an important candidate risk factor for especially CRVO. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENDOTHELIUM
*EPITHELIUM
*PROTEINS
*RETINA
*PROTEIN C
Subjects
Details
- Language :
- English
- ISSN :
- 14426404
- Volume :
- 34
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 20986111
- Full Text :
- https://doi.org/10.1111/j.1442-9071.2006.01212.x