Synthesis and antibacterial activity of nocathiacin I analogues

Authors :: Naidu, B. Narasimhulu
Sorenson, Margaret E.
Matiskella, John D.
Li, Wenying
Sausker, Justin B.
Zhang, Yunhui
Connolly, Timothy P.
Lam, Kin S.
Bronson, Joanne J.
Pucci, Michael J.
Yang, Hyekyung
Ueda, Yasutsugu
Source :: Bioorganic & Medicinal Chemistry Letters. Jul2006, Vol. 16 Issue 13, p3545-3549. 5p.
Publication Year :: 2006
Abstract: Abstract: Stereoselective reduction of dehydroalanine double bond in nocathiacin I afforded the primary amide 2. Enzymatic hydrolysis of the amide 2 provided the carboxylic acid 3, which upon coupling with a variety of amines furnished amides 4–32. Some of these semi-synthetic derivatives have retained very good antibacterial activity and have improved aqueous solubility. [Copyright &y& Elsevier]