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Structure–activity studies of oxazolidinone analogs as RNA-binding agents
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jul2006, Vol. 16 Issue 13, p3600-3604. 5p. - Publication Year :
- 2006
-
Abstract
- Abstract: We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones. [Copyright &y& Elsevier]
- Subjects :
- *NUCLEIC acids
*RNA
*OXAZOLES
*HETEROCYCLIC compounds
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 21049357
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.03.068