Thymic Volume Predicts CD4 T-Cell Decline in HIV-Infected Adults Under Prolonged Treatment Interruption.

The article analyzes the predictive capacity of thymic volume in CD4 T-cell loss after prolonged treatment interruption in a group of immunologically preserved HIV-infected patients with nadir CD4 count greater than 250 cells/µL. Multivariate Cox proportional hazards regression models were used to analyze all variables with statistical association with CD4 T-cell loss. Twenty-three percent of the patients had a reduction in CD4 count to less than 350 cells/µL. Thymic volume and CD4 T-cell loss were independently associated using the model.