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The article provides information about the research on motheaten mouse in the U.S. Motheaten mouse was first discovered by Leonard Shultz at the Jackson laboratories. It was initially of interest for its immune deficiency and autoimmune phenotypes and its name reflects a motheaten appearance due to hair loss. It was used to clarify the role of signal transduction pathways in hemotopoietic cells although these mice have later proven useful for studying the physiological roles of signal transduction.