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Preparation and characterization of chitosan–poly(acrylic acid) polymer magnetic microspheres
- Source :
-
Polymer . Jul2006, Vol. 47 Issue 15, p5287-5294. 8p. - Publication Year :
- 2006
-
Abstract
- Abstract: A modified method to prepare chitosan–poly(acrylic acid)(CS–PAA) polymer magnetic microspheres was reported in this paper. First, via self-assembly of positively charged CS and negatively charged Fe3O4 nanoparticles, magnetic CS cores with a large amount of Fe3O4 nanoparticles were successfully prepared. Subsequently, the AA monomers were polymerized on the magetic CS cores based on the reaction system of water-soluble polymer–monomer pairs. These polymer magnetic microspheres had a high Fe3O4 loading content, and showed unique pH-dependent behaviors on the size and zeta potential. From the magnetometer measurements data, the CS–PAA polymer magnetic microspheres also had superparamagnetic property as well as fast magnetic response. A continuous release of the entrapped ammonium glycyrrhizinate in such polymer magnetic microspheres occurred, which confirmed the potential applications of these microspheres for the targeted delivery of drugs. [Copyright &y& Elsevier]
- Subjects :
- *CHITOSAN
*CHITIN
*ACRYLIC acid
*POLYMERS
*NANOPARTICLES
Subjects
Details
- Language :
- English
- ISSN :
- 00323861
- Volume :
- 47
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Polymer
- Publication Type :
- Academic Journal
- Accession number :
- 21576958
- Full Text :
- https://doi.org/10.1016/j.polymer.2006.05.017